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Protective capacity of Rosemary extract against radiation induced hepatic injury in mice
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D. Soyal   , A. Jindal , I. Singh , P.K. Goyal |
| , pkgoyal2002@rediffmail.com |
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Abstract: (19667 Views) |
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Background: This study was carried out to observe
the radioprotective effects of Rosemarinus officinalis
leaves extract (ROE) against radiation-induced
histopathological alterations in liver of mice.
Materials and Methods: Adult Swiss albino mice
were exposed to 6 Gy gamma radiation in the
presence (experimental) or absence (control) of ROE to
study the qualitative and quantitative alterations in the
liver. Results: Normal hepatocyte counts were found
to be declined up to day 10th post-irradiation in both
the groups but thereafter such cells increased
reaching to near normal level at the last autopsy
interval, only in experimental group. Contrary,
frequency of abnormal hepatocytes increased up to
day 10th after irradiation in both the groups.
Binucleate hepatic cells showed a biphasic mode of
elevation after irradiation, first at 12 hrs and second
on day 10th in control group whereas in experimental
group, the elevation was comparatively less marked
and even the second peak was not evident. Irradiation
of animals resulted in an elevation in lipid peroxidation
(LPx) and a significant decrease in glutathione (GSH)
concentration in liver as well as in blood. Conversely,
experimental group showed a significant decline in LPx
and an elevation in GSH concentration. Conclusion:
These results indicate that Rosemarinus officinalis
leaves extract (ROE) is able to protect the liver of Swiss
albino mice against radiation induced histopathological
alterations. Iran. J. Radiat. Res., 2007 4 (4): 161-
168 |
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| Keywords: Irradiation, liver, Rosemarinus officinalis, Swiss albino mice, hepatic cell counts. |
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Full-Text [PDF 592 kb]
(3650 Downloads)
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Type of Study: Original Research |
Subject:
Radiation Biology
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