en Radiation Biology Radiation Biology تحقيق بديع Original Research <span style="font-weight: bold;">Background:</span> As bremsstrahlung photon beam fluence is important parameter to be known in a photonuclear reaction experiment as the number of produced particle is strongly depends on photon fluence. <span style="font-weight: bold;">Materials and Methods:</span> Photon production yield from different thickness of aluminum target has been estimated using artificial neural network (ANN) model. Target thickness and incoming electron energy has been used as input in ANN model and the photon fluence was output. <span style="font-weight: bold;">Results:</span> The results were estimated using ANN model for three different thickness and compared with the results obtained by EGS (Electron Gamma Shower) simulation. <span style="font-weight: bold;">Conclusion: </span>It can be concluded from this work that the bremsstrahlung photon fluence can be obtained using ANN model. <span style="font-weight: bold;">Iran. J. Radiat. Res., 2012; 10(1): 63-65 </span> ANN, EGS, photon fluence 63 65 http://www.ijrr.com/browse.php?a_code=A-10-1-422&amp;slc_lang=en&amp;sid=en I. Akkurt iskenderakkurt@sdu.edu.tr 790031947532846002712 Yes Suleyman Demirel University, Science and Arts Faculty Physics Department, Isparta, Turkey K. Gunoglu 790031947532846002713 No Suleyman Demirel University, Science and Arts Faculty Physics Department, Isparta, Turkey H.O. Tekin 790031947532846002714 No Suleyman Demirel University, Science and Arts Faculty Physics Department, Isparta, Turkey Z.N. Demirci 790031947532846002715 No Suleyman Demirel University, Science and Arts Faculty Physics Department, Isparta, Turkey G. Yegin 790031947532846002716 No Celal Bayar University, Science and Arts Faculty Physics Department, Manisa, Turkey D. Demir 790031947532846002717 No Uludag University, Science and Arts Faculty Physics Department, Bursa, Turkey