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 | Volume 8, Number 3 (12-2010) |  | |
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 | Post-treatment effects of Alstonia scholaris extract against radiation-induced biochemical alterations in Swiss albino mice |  |
| | Author(s): U. Gupta, R. Chaudhary , Dr. P.K. Goyal * | | * - Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur 302 004, India , pkgoyal2002@gmail.com | | Study Type: Original Research | Subject: Radiation Biology | | | Article abstract: | |
Background: This study has been undertaken to
find out the possible radioprotective potential of the
Alstonia scholaris extract (ASE). Materials and
Methods: For experimental study, healthy Swiss
albino male mice were selected from an inbred
colony and divided in four groups. Group I (normal)
did not receive any treatment. Group II was orally
supplemented ASE once daily at the dose of 100 mg/
kg.b.wt/day for 5 consecutive days. Group III (control)
received distilled water orally equivalent to ASE for 5
days then exposed to 7.5 Gy of gamma radiation.
Group IV (experimental) was administered orally ASE
for 5 consecutive days once daily and exposed to
single dose of 7.5 Gy of gamma radiation. Mice were
sacrificed at different autopsy intervals viz. 12 hrs. 1,
3,7,15 and 30 days, and their liver and blood were
taken for various biochemical estimations viz. lipid
peroxidation (LPO), reduced glutathione (GSH),
protein and cholesterol. Results: Radiation induced
augmentation in lipid peroxidation and cholesterol
was significantly ameliorated by ASE extract and
deficit produced in protein and glutathione content by
radiation was checked. Conclusion: Alstonia scholaris
extract pretreatment hence renders protection
against radiation-induced biochemical alterations in
mice. Iran. J. Radiat. Res., 2010; 8 (3): 169-177 | | | Keywords: Alstonia scholaris, gutathione, lipid peroxidation, radioprotection, mice., | |
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