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Modulation of radiation and cadmium induced biochemical changes in mouse kidney by Emblica officinalis Linn
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A. Chakrawarti   , R.K. Purohit , M. Agarwal , P. Joshi , A. Basu , K.M. Bhartiya , A. Bhardwaj |
| , dr_rajendra_purohit@yahoo.co.in |
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Abstract: (11045 Views) |
| Background: Protective effect of Emblica against
radiation and cadmium induced biochemical changes in
mouse kidney has been studied. Materials and Methods:
Adult male mice were divided into seven groups: I (shamirradiated),
II (cadmium chloride), III (irradiated with 2 Gy
gamma rays), IV (radiation and cadmium chloride), V
(Cadmium chloride and Emblica), VI (radiation and
Emblica), VII (radiation, cadmium chloride and Emblica).
The animals were autopsied after 1-28 days of treatment.
The kidney was taken out and different biochemical
parameters such as total proteins, glycogen, cholesterol,
acid phosphatase activity, alkaline phosphatase activity,
DNA and RNA were estimated. Results: The value of glycogen,
RNA, acid phosphatase and alkaline phosphatase
activity increased up to day-14 in non drug treated groups
and day-7 in the Emblica treated groups and thereafter
decreased up to the last autopsy interval. The value of
cholesterol and DNA decreased up to day-14 in non drug
treated groups and day 7 in the drug treated groups then
increased in all the groups. In groups III, IV, VI and VII the
value of total proteins increased during early intervals and
decreased thereafter, but the animals of groups II and V,
which were given only cadmium chloride with or without
Emblica, showed an opposite trend. The biochemical
parameters showed highly significant values (p<0.001) as
compared to normal ones. Conclusion: Results indicated
that combined treatment of radiation and cadmium
chloride exerts synergistic effect. The drug treated animals
showed less severe biochemical changes and an early and
fast recovery, which may be due to protection provided by
Emblica. Iran. J. Radiat. Res., 2010 8 (1): 3-10 |
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| Keywords: Radiation, cadmium, Emblica, kidney, mice. |
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Full-Text [PDF 332 kb]
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Type of Study: Original Research |
Subject:
Radiation Biology
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